Malaria remains a significant public health challenge, particularly in endemic regions, where it contributes to substantial morbidity and mortality. Hematological alterations are common complications in malaria infections and can influence disease severity and patient outcomes. This study aimed to investigate the hematological changes in patients diagnosed with malaria and to assess the correlation between these changes and clinical presentations.

A cross-sectional study was conducted involving 150 patients with confirmed malaria infection attending a tertiary care hospital over six months. Complete blood counts were performed using automated hematology analyzers, and parameters such as hemoglobin levels, white blood cell counts, platelet counts, and red blood cell indices were analyzed. Data were statistically evaluated to determine the prevalence and pattern of hematological abnormalities associated with malaria.

The study revealed significant hematological alterations, including anemia in 68% of patients, thrombocytopenia in 74%, and leukopenia in 38%. Severity of anemia and thrombocytopenia correlated with parasite load and clinical symptoms. These findings highlight the frequent occurrence of hematological disturbances in malaria and their potential as markers for disease severity.