Background: Pyoderma, a common bacterial skin infection, presents a significant healthcare burden, especially in tropical and developing regions. It is broadly classified into primary and secondary types, depending on whether the infection arises in previously healthy skin or over pre-existing dermatoses. The increasing incidence of antibiotic resistance among causative organisms necessitates updated regional data to guide empirical therapy effectively.

Objective: This prospective hospital-based study aimed to identify the spectrum of causative bacterial organisms responsible for pyoderma and assess their antimicrobial susceptibility patterns to aid in evidence-based treatment planning.

Methods: A total of [insert number] clinically diagnosed pyoderma cases were enrolled over a period of [insert duration] at [insert hospital name]. Patients were classified into primary or secondary pyoderma based on clinical criteria. Pus or wound swabs were collected under aseptic precautions and subjected to Gram staining, culture, and sensitivity testing using standard microbiological techniques. Antibiotic susceptibility was determined using the Kirby-Bauer disk diffusion method following CLSI guidelines.

Results: Among the isolates, Staphylococcus aureus was the predominant pathogen, accounting for [insert percentage] of cases, followed by Streptococcus pyogenes and various Gram-negative bacilli. A significant proportion of S. aureus isolates were methicillin-resistant (MRSA), highlighting a concerning trend in resistance. Gram-negative organisms showed varying susceptibility patterns, with notable resistance to commonly used antibiotics such as ampicillin and co-trimoxazole. However, most isolates remained sensitive to linezolid, vancomycin (for Gram-positives), and carbapenems (for Gram-negatives).